Natasha Hezelgrave
Natasha Hezelgrave,
 
Current Post: NIHR Doctoral Research Fellow Obstetrics and Gynaecology Oct  ’12- curr
                      Women’s Health Academic Centre, Kings College London                                                                  
                      Supervisors: Professor Andrew Shennan, Dr Rachel Tribe   
Qualifications: MRCOG Part 1 Mar ‘10
                       Full GMC Registration Aug ‘08
                       MBBS (QMUL, Distinction in Clinical Science and Distinction in Clinical Practice.
                       Proxime Accessit to University of 
London Gold Medal) Jul ‘07
                       BSc (International Health, UCL, First Class Hons.) Jul  ‘04
               
Currently an NIHR doctoral research fellow in obstetrics and gynaecology, my research interest is in the prediction and prevention of spontaneous preterm birth.  I am currently studying the role of the innate immune system in the pathophysiology of preterm birth, and have just started an RCT of cerclage, progesterone and Arabin pessary for the prevention of preterm birth.   
RESEARCH
Current Projects
Prediction of preterm birth using novel biomarkers  Curr
CRADLE 2: ‘Community Blood Pressure Monitoring in rural Africa: Curr              
detection of Pre-eclampsia’.  Co- investigator
Previous Projects
Advisor to WHO: Preterm Birth Guideline Development 2014
Advisor to WHO: Global Pre-eclampsia research strategy  2013       
CRADLE: ‘Community Blood Pressure Monitoring in rural Africa:                          
detection of Pre-eclampsia’- International multi-country intervention study
Co-applicant, Research coordinator Oct ’10-Dec ‘12
Advisor to the WHO: Post Partum Haemorrhage technical Jan ’12- Jul ‘12
consultation and member of guideline development committee.
Situational Analysis of maternal health systems in the Brong-Ahafo Dec ’08
region, Ghana (LSHTM, PI: B Kirkwood)
Grants achieved
£300,000 NIHR Clinical Fellowship: Prevention of Preterm Birth Oct’ 13
$1,000,000 Bill and Melinda Gates Foundation: CRADLE 2 Jul’ 13
£86,350 Rosetrees Foundation: ‘Biomarkers for the Prediction of Spontaneous
Preterm Birth May ‘13
£4000 BMFMS: Elafin and prediction of preterm birth March ‘13
$100,000 Gates Foundation Grand Challenges Expeditions, ‘CRADLE’ Dec ‘10
Publications
Research
                                                               
Nathan HL, de Greeff A, Hezelgrave NL, Chappell LC, Shennan AH  Accuracy validation of the Microlife 3AS1-2 blood pressure device in a pregnant population with low blood pressure. Blood Press Monit. 2015 In press
Kuhrt K, Hezelgrave N, Foster C, Seed PT, Shennan AH. Development and validation of a predictive tool for spontaneous preterm birth, incorporating quantitative fetal fibronectin, in symptomatic women. Ultrasound Obstet Gynecol. 2015 May 11. doi: 10.1002/uog.14894
Abbott D, Hezelgrave NL, Seed P, Norman J, Bennett P, David AL et al. Quantitative fetal fibronectin to predict risk in asymptomatic women at high risk.  Obsteterics and Gynaecology 2015. 125(5):1168-76.
Kuhrt K, Smout E, Hezelgrave N, Seed PT, Carter J, Shennan AH. Development and validation of a predictive tool for spontaneous preterm birth incorporating cervical length and quantitative fetal fibronectin in asymptomatic high-risk women. Ultrasound Obstet Gynecol. 2015; doi: 10.1002/uog.14865
Vousden N, Hezelgrave NL, Carter J, Seed P, Shennan AH. Prior ultrasound-indicated cerclage: how should we manage the next pregnancy? Eur J Obs Gynecol Reprod Biol 2015; 188:129-32
Nathan HL, El Ayadi A, Hezelgrave NL, Seed P, Butrick E, Miller S, Briley A, Bewley S, Shennan AH. Shock Index: An Effective Predictor of Outcome in Postpartum Haemorrhage? BJOG 2015;122:268275.
Nathan H, De Greeff A, Hezelgrave N, Shennan AH. An accurate semi-automated oscillometric blood pressure device for use in pregnancy (including pre-eclampsia) in a low- and middle-income country population: the Microlife 3AS1-2.   Blood Press Monit 2014 (In press)
McClaren J, Hezelgrave NL, Ayubi H, Seed P, Shennan AH. Prediction of spontaneous preterm birth using quantitative fetal fibronectin after recent sexual intercourse.  AJOG 2014 pii: S0002-9378(14)00635-8
Kuhrt K, Uwin C, Hezelgrave N, Shennan A. Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth.  The Journal of Maternal Fetal & Neonatal Medicine 2014;27(15):1576-9
Tezcan B, Hezelgrave N, Shennan A. The role of cervical ultrasound screening in determining the timing of emergency cerclage. J Obstet Gynaecol. 2012 Jul;32:444-6.
Baker E, Hezelgrave N, Magesa S, Edmonds S, de Greeff A, Shennan A.  Introduction of automated blood pressure devices intended for a low resource setting, in rural Tanzania.  Tropical Doctor.  2012 Apr;42:101-3
De Greef A, Hezelgrave N, Shennan A. Accuracy assessment of a novel blood pressure measurement device in a South African adult population: Tensoval Duo-Control. Blood Press Monit. 2011 ;16:304-6.
Reviews
Hezelgrave NL, Shennan AH. Prediction of spontaneous preterm birth using quantitative fetal fibronectin.  Future Medicine. In Press 2015
Hezelgrave NL, Shennan AH, David AL. Rational testing: Tests to predict delivery in threatened preterm labour. BMJ 2015; 350:h2183.
Anderson-Knight H, Cull F, Hezelgrave N, Shennan A (2015) The Role of Portable Ultrasound in a Global Setting. J Preg Child Health 2: 143. doi:10.4172/2376-127X.1000143
Hezelgrave N, Rajasingham D, Shennan A, Torloni MR. Mild gestational diabetes: towards a redefined threshold? Expert Rev. Endoc. Metab 2012;7:669-676.
Hezelgrave N, Duffy S, Shennan A. Preventing the preventable. The contribution of hypertensive disorders of pregnancy to global maternal mortality.  Obstetrics, Gynaecology and Reproductive Medicine. 2012;22:170-172
Hezelgrave N, Whitty C, Shennan A, Chappell L.  Advising on travel in pregnancy. BMJ 2011; 342:1074-1078
Hezelgrave N, Oteng-Ntim E. Bariatric surgery and pregnancy: A review.  J Obes 2011: 501939.
Hezelgrave N. Family structure and stability in the causation of the street child phenomenon. Lancet online publication. Published June 8 2005. www.thelancet.com/collections/student_essays
Guidelines
World Health Organisation. WHO Recommendations for the prevention and treatment of post-partum haemorrhage.  WHO 2012.
Commentary
Hezelgrave NL, Anderson-Knight H, Webster L, Shennan AH. Commentary on ‘A multi-centre randomised control trial comparing elective and selective caesarian section for the delivery of the preterm breech. British Journal of Obstetrics and Gynaecology, 2014; 121 (Supp.7): 54-57
Hezelgrave NL, Shennan AH. Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections: RHL commentary. The WHO Reproductive Health Library; Geneva: World Health Organization. 2012.
Shennan A, Hezelgrave NL. Clinical trials need economic evaluation. British Journal of Obstetrics and Gynaecology. 2010; DOI: 10.1111/j.1471-0528.2010.02727.
Case Reports
Anderson-Knight H, Hezelgrave NL, Shennan AH.  Spontaneous resolution of a mid-trimester dilated cervix with expectant management guided by quantitative fetal fibronectin results. J Obstet Gynaecol. 2015. In Press
Hall M, Vousden N, Carter J, Hezelgrave NL, Shennan AH. Prevention of mid-trimester loss following full dilatation caesarean section: A potential role for transabdominal cervical cerclage.  J Obstet Gynaecol. 2015 Jan;35(1):98-9
Gibson S, Hezelgrave NL, Shennan AH. Management of vasa praevia: A potential role for cervical length and quantitative fetal fibronectin measurement. J Obstet Gynaecol. 2013 Nov;33(8):905
Hezelgrave NL, Srinivas K, Ahmad I, Mascarenhas I.  Use of awake oral fibreoptic intubation for caesarean section in a woman with Goldenhar Syndrome. European Journal of Obstetrics, Gynaecology and Reproductive Biology 2011; 159: 479-480.
Invited lectures/talks
PPH and Pre-eclampsia: Avoiding Substandard Care: Obstetrics and Neonatal Dec ‘14
Dilemmas Conference 2015, Dublin
Prediction of Preterm birth using fetal fibronectin: European Spontaneous May ‘14
Preterm Birth Congress 2014, Denmark
Draft WHO Post-Partum Haemorrhage Recommendations March ‘12
WHO Technical Consultation Meeting Montreux, Switzerland
Book chapters
Hezelgrave NL, Shennan AH. Threatened and Actual Preterm Birth.  In: High Risk Dec ‘14
Pregnancy: Management Options. Cambridge University Press, In Production
Hezelgrave NL, Lee, G. Shennan AH.Rescue Cerclage after bulging membranes: Dec ‘14
delaying the inevitable? In: Challenging concepts in Obstetrics and Gynaecology. 
Oxford University Press, 2014
Hall M, Hezelgrave NL, Shennan AH. Global challenges in the identification July ‘14
and management of preeclampsia. In: Advances in Medical Biology Vol 80,
Nova Publishers, 2014
Books
Co-Editor ‘Challenging Concepts in Obstetrics and Gynaecology’  Dec ‘14
2014 Oxford University Press, Oxford