Mobasheri 100Surname: Mobasheri                                            
Forename: Ali

Address: Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire, LE12 5RD, United Kingdom

Education and Academic Qualifications:

Bachelor of Science (B.Sc.) - Upper Second Class Honours, Biochemistry. Imperial College London, July 1990.

Associate of the Royal College of Science (A.R.C.S.) - Upper Second Class Honours, Imperial College London, July 1990.

Master of Science (M.Sc.) - Physiology & Biochemistry. University of Toronto, Toronto, Ontario, Canada, March 1993.

Doctor of Philosophy (D.Phil.) - Cellular & Molecular Physiology. Wolfson College, University of Oxford, Oxford, March 1997.

Posts Held:

1997 – 2000: Lecturer and Senior Lecturer in Cellular and Molecular Biology, University of Westminster (HEFCE funded post)

2000 – 2005: Lecturer in Veterinary Biology, University of Liverpool (HEFCE funded post)

2005 – 2006: University Senior Lecturer, University of Liverpool (HEFCE funded post)

2006 – Present: Associate Professor, Reader in Comparative Physiology, School of Veterinary Medicine and Science, University of Nottingham (HEFCE funded post)

Scopus Author ID 7003311894; Hirsch (h) index 26; 1914 citations

Publications: (1-126)

1.         Shakibaei M, Allaway D, Nebrich S, Mobasheri A. Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1beta-Induced NF-kappaB Activation in Canine Articular Chondrocytes. Evid Based Complement Alternat Med. 2012;2012:509383.

2.         Aralla M, Mobasheri A, Groppetti D, Cremonesi F, Arrighi S. Expression of aquaporin water channels in canine fetal adnexa in respect to the regulation of amniotic fluid production and absorption. Placenta. 2012 Mar 17.

3.         Henrotin Y, Mobasheri A, Marty M. Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther. 2012 Jan 30;14(1):201.

4.         Mobasheri A. Proteomic profiling and its applications to muscle aging and sarcopenia. Front Physiol. 2011;2:117.

5.         Mobasheri A. Applications of proteomics to osteoarthritis, a musculoskeletal disease characterized by aging. Front Physiol. 2011;2:108.

6.         Penny J, Harris P, Shakesheff KM, Mobasheri A. The biology of equine mesenchymal stem cells: phenotypic characterization, cell surface markers and multilineage differentiation. Front Biosci. 2012;17:892-908.

7.         Montaseri A, Busch F, Mobasheri A, Buhrmann C, Aldinger C, Rad JS, et al. IGF-1 and PDGF-bb suppress IL-1beta-induced cartilage degradation through down-regulation of NF-kappaB signaling: involvement of Src/PI-3K/AKT pathway. PLoS One. 2011;6(12):e28663.

8.         Mobasheri A. Identification and phenotypic characterisation of chondroprogenitor cells for the repair of equine articular cartilage. Vet J. 2011 Oct 14.

9.         Shakibaei M, Buhrmann C, Mobasheri A. Anti-inflammatory and anti-catabolic effects of TENDOACTIVE(R) on human tenocytes in vitro. Histol Histopathol. 2011 Sep;26(9):1173-85.

10.        Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2011 Aug 12;286(32):28556-66.

11.        Mobasheri A. Identification and validation of early biomarkers of osteoarthritis in companion animals: are we ready for the challenge? Vet J. 2011 Oct;190(1):1-4.

12.        Williams A, Smith JR, Allaway D, Harris P, Liddell S, Mobasheri A. Applications of proteomics in cartilage biology and osteoarthritis research. Front Biosci. 2012;17:2622-44.

13.        Acosta E, Avila J, Mobasheri A, Martin-Vasallo P. Na+, K+-ATPase genes are down-regulated during adipose stem cell differentiation. Front Biosci (Elite Ed). 2011;3:1229-40.

14.        Shakibaei M, Mobasheri A, Buhrmann C. Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes Nutr. 2011 May;6(2):171-9.

15.        Medina-Torres CE, Mason SL, Floyd RV, Harris PA, Mobasheri A. Hypoxia and a hypoxia mimetic up-regulate matrix metalloproteinase 2 and 9 in equine laminar keratinocytes. Vet J. 2011 Nov;190(2):e54-9.

16.        Schneider PR, Buhrmann C, Mobasheri A, Matis U, Shakibaei M. Three-dimensional high-density co-culture with primary tenocytes induces tenogenic differentiation in mesenchymal stem cells. J Orthop Res. 2011 Sep;29(9):1351-60.

17.        Clutterbuck AL, Smith JR, Allaway D, Harris P, Liddell S, Mobasheri A. High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation. J Proteomics. 2011 May 1;74(5):704-15.

18.        Lewis R, Asplin KE, Bruce G, Dart C, Mobasheri A, Barrett-Jolley R. The role of the membrane potential in chondrocyte volume regulation. J Cell Physiol. 2011 Nov;226(11):2979-86.

19.        Mobasheri A, Barrett-Jolley R, Carter SD, Martin-Vasallo P, Schulze-Tanzil G, Shakibaei M. Functional Roles of Mechanosensitive Ion Channels, ss1 Integrins and Kinase Cascades in Chondrocyte Mechanotransduction. 2005.

20.        Mobasheri A, Barrett-Jolley R, Shakibaei M, Canessa CM, Martin-Vasallo P. Enigmatic Roles of the Epithelial Sodium Channel (ENaC) in Articular Chondrocytes and Osteoblasts: Mechanotransduction, Sodium Transport or Extracellular Sodium Sensing? 2005.

21.        Shakibaei M, Buhrmann C, Mobasheri A. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem. 2011 Apr 1;286(13):11492-505.

22.        Cornock R, Langley-Evans SC, Mobasheri A, McMullen S. The impact of maternal protein restriction during rat pregnancy upon renal expression of angiotensin receptors and vasopressin-related aquaporins. Reprod Biol Endocrinol. 2010;8:105.

23.        Buhrmann C, Mobasheri A, Matis U, Shakibaei M. Curcumin mediated suppression of nuclear factor-kappaB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther. 2010;12(4):R127.

24.        Freeman A, Hetzel U, Cripps P, Mobasheri A. Expression of the plasma membrane markers aquaporin 1 (AQP1), glucose transporter 1 (GLUT1) and Na, K-ATPase in canine mammary glands and mammary tumours. Vet J. 2010 Jul;185(1):90-3.

25.        Mobasheri A, Henrotin Y. Identification, validation and qualification of biomarkers for osteoarthritis in humans and companion animals: mission for the next decade. Vet J. 2010 Aug;185(2):95-7.

26.        Mobasheri A, Cassidy JP. Biomarkers in veterinary medicine: Towards targeted, individualised therapies for companion animals. Vet J. 2010 Jul;185(1):1-3.

27.        Ghuman SP, Morris R, Scherzer J, Routly JE, Mobasheri A, Smith RF, et al. Neuronal responses in the brainstem and hypothalamic nuclei following insulin treatment during the late follicular phase in the ewe. Reprod Domest Anim. 2011 Feb;46(1):121-9.

28.        Airley R, Evans A, Mobasheri A, Hewitt SM. Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays. Ann Anat. 2010 May 20;192(3):133-8.

29.        Boone M, Mobasheri A, Fenton RA, van Balkom BW, Wismans R, van der Zee CE, et al. The lysosomal trafficking regulator interacting protein-5 localizes mainly in epithelial cells. J Mol Histol. 2010 Feb;41(1):61-74.

30.        Mobasheri A, Barrett-Jolley R. Transient receptor potential channels: emerging roles in health and disease. Vet J. 2011 Feb;187(2):145-6.

31.        Summerfield N, Peters ME, Hercock CA, Mobasheri A, Young IS. Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium. J Vet Cardiol. 2010 Apr;12(1):17-23.

32.        Mobasheri A, Lewis R, Maxwell JE, Hill C, Womack M, Barrett-Jolley R. Characterization of a stretch-activated potassium channel in chondrocytes. J Cell Physiol. 2010 May;223(2):511-8.

33.        Mobasheri A, Moskaluk CA, Marples D, Shakibaei M. Expression of aquaporin 1 (AQP1) in human synovitis. Ann Anat. 2010 Apr 20;192(2):116-21.

34.        Floyd RV, Wray S, Quenby S, Martin-Vasallo P, Mobasheri A. Expression and distribution of Na, K-ATPase isoforms in the human uterus. Reprod Sci. 2010 Apr;17(4):366-76.

35.        Barrett-Jolley R, Lewis R, Fallman R, Mobasheri A. The emerging chondrocyte channelome. Front Physiol. 2010;1:135.

36.        Rauch C, Pluen A, Foster N, Loughna P, Mobasheri A, Lagadic-Gossmann D, et al. On some aspects of the thermodynamic of membrane recycling mediated by fluid phase endocytosis: evaluation of published data and perspectives. Cell Biochem Biophys. 2010 Apr;56(2-3):73-90.

37.        Eckersall PD, Slater K, Mobasheri A. Biomarkers in veterinary medicine: establishing a new international forum for veterinary biomarker research. Biomarkers. 2009 Dec;14(8):637-41.

38.        Noble K, Floyd R, Shmygol A, Mobasheri A, Wray S. Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Cell Calcium. 2010 Jan;47(1):47-54.

39.        Clutterbuck AL, Asplin KE, Harris P, Allaway D, Mobasheri A. Targeting matrix metalloproteinases in inflammatory conditions. Curr Drug Targets. 2009 Dec;10(12):1245-54.

40.        Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther. 2009;11(6):R165.

41.        Floyd RV, Wray S, Martin-Vasallo P, Mobasheri A. Differential cellular expression of FXYD1 (phospholemman) and FXYD2 (gamma subunit of Na, K-ATPase) in normal human tissues: a study using high density human tissue microarrays. Ann Anat. 2010 Feb 20;192(1):7-16.

42.        Mobasheri A, Kendall BH, Maxwell JE, Sawran AV, German AJ, Marples D, et al. Cellular localization of aquaporins along the secretory pathway of the lactating bovine mammary gland: an immunohistochemical study. Acta Histochem. 2011 Feb;113(2):137-49.

43.        Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, et al. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 2010 Feb;18(2):141-9.

44.        Graham NS, Clutterbuck AL, James N, Lea RG, Mobasheri A, Broadley MR, et al. Equine transcriptome quantification using human GeneChip arrays can be improved using genomic DNA hybridisation and probe selection. Vet J. 2010 Dec;186(3):323-7.

45.        Richardson SM, Hoyland JA, Mobasheri R, Csaki C, Shakibaei M, Mobasheri A. Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. J Cell Physiol. 2010 Jan;222(1):23-32.

46.        Clutterbuck AL, Mobasheri A, Shakibaei M, Allaway D, Harris P. Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann N Y Acad Sci. 2009 Aug;1171:428-35.

47.        Rosa SC, Goncalves J, Judas F, Mobasheri A, Lopes C, Mendes AF. Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Res Ther. 2009;11(3):R80.

48.        Ratcliffe L, Mian S, Slater K, King H, Napolitano M, Aucoin D, et al. Proteomic identification and profiling of canine lymphoma patients. Vet Comp Oncol. 2009 Jun;7(2):92-105.

49.        Ratcliffe L, Mian S, Slater K, King H, Napolitano M, Aucoin D, et al. Proteomic identification and profiling of canine lymphoma patients*. Vet Comp Oncol. 2009 Mar 4.

50.        Mobasheri A, Csaki C, Clutterbuck AL, Rahmanzadeh M, Shakibaei M. Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy. Histol Histopathol. 2009 Mar;24(3):347-66.

51.        Clutterbuck AL, Harris P, Allaway D, Mobasheri A. Matrix metalloproteinases in inflammatory pathologies of the horse. Vet J. 2010 Jan;183(1):27-38.

52.        Peansukmanee S, Vaughan-Thomas A, Carter SD, Clegg PD, Taylor S, Redmond C, et al. Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo. J Orthop Res. 2009 Apr;27(4):529-35.

53.        Csaki C, Matis U, Mobasheri A, Shakibaei M. Co-culture of canine mesenchymal stem cells with primary bone-derived osteoblasts promotes osteogenic differentiation. Histochem Cell Biol. 2009 Feb;131(2):251-66.

54.        Mobasheri A, Bondy CA, Moley K, Mendes AF, Rosa SC, Richardson SM, et al. Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines. Adv Anat Embryol Cell Biol. 2008;200:1 p following vi, -84.

55.        Clutterbuck A, Harris P, Mobasheri A. Comment on: comparison between chondroprotective effects of glucosamine, curcumin and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. Osteoarthritis Cartilage. 2009 Jan;17(1):135-6; author reply 7.

56.        Shakibaei M, Csaki C, Mobasheri A. Diverse roles of integrin receptors in articular cartilage. Adv Anat Embryol Cell Biol. 2008;197:1-60.

57.        Shakibaei M, Csaki C, Nebrich S, Mobasheri A. Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem Pharmacol. 2008 Dec 1;76(11):1426-39.

58.        Richardson SM, Knowles R, Marples D, Hoyland JA, Mobasheri A. Aquaporin expression in the human intervertebral disc. J Mol Histol. 2008 Jun;39(3):303-9.

59.        Richardson SM, Knowles R, Tyler J, Mobasheri A, Hoyland JA. Expression of glucose transporters GLUT-1, GLUT-3, GLUT-9 and HIF-1alpha in normal and degenerate human intervertebral disc. Histochem Cell Biol. 2008 Apr;129(4):503-11.

60.        Csaki C, Matis U, Mobasheri A, Ye H, Shakibaei M. Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ultrastructural study. Histochem Cell Biol. 2007 Dec;128(6):507-20.

61.        Sutton S, Clutterbuck A, Harris P, Gent T, Freeman S, Foster N, et al. The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Vet J. 2009 Jan;179(1):10-24.

62.        Airley RE, Mobasheri A. Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics. Chemotherapy. 2007;53(4):233-56.

63.        Richardson SM, Mobasheri A, Freemont AJ, Hoyland JA. Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies. Histol Histopathol. 2007 Sep;22(9):1033-41.

64.        Floyd RV, Mason SL, Proudman CJ, German AJ, Marples D, Mobasheri A. Expression and nephron segment-specific distribution of major renal aquaporins (AQP1-4) in Equus caballus, the domestic horse. Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R492-503.

65.        Shakibaei M, John T, Seifarth C, Mobasheri A. Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann N Y Acad Sci. 2007 Jan;1095:554-63.

66.        Mobasheri A, Platt N, Thorpe C, Shakibaei M. Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. Ann N Y Acad Sci. 2006 Dec;1091:83-93.

67.        John T, Kohl B, Mobasheri A, Ertel W, Shakibaei M. Interleukin-18 induces apoptosis in human articular chondrocytes. Histol Histopathol. 2007 May;22(5):469-82.

68.        Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007 May 1;73(9):1434-45.

69.        Mobasheri A, Marples D, Young IS, Floyd RV, Moskaluk CA, Frigeri A. Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles. Channels (Austin). 2007 Jan-Feb;1(1):29-38.

70.        Simpson DM, Mobasheri A, Haywood S, Beynon RJ. A proteomics study of the response of North Ronaldsay sheep to copper challenge. BMC Vet Res. 2006;2:36.

71.        Mobasheri A. Colony-stimulating factors in veterinary medicine: an unexplored potential. Vet J. 2007 Jul;174(1):8-9.

72.        Shakibaei M, Seifarth C, John T, Rahmanzadeh M, Mobasheri A. Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem Pharmacol. 2006 Nov 30;72(11):1382-95.

73.        Mobasheri A, Gent TC, Nash AI, Womack MD, Moskaluk CA, Barrett-Jolley R. Evidence for functional ATP-sensitive (K(ATP)) potassium channels in human and equine articular chondrocytes. Osteoarthritis Cartilage. 2007 Jan;15(1):1-8.

74.        Mobasheri A. Comment on: cloning and characterization of porcine aquaporin 1 water channel expressed extensively in the gastrointestinal system. World J Gastroenterol. 2006 Jul 21;12(27):4437-9.

75.        Mobasheri A. A new low temperature method for high yield isolation of chondrocytes from elderly human subjects and its applicability to mature articular cartilage from older animals. Osteoarthritis Cartilage. 2006 Jul;14(7):720-1.

76.        Haisch A, Marzahn U, Mobasheri A, Schulze-Tanzil G, Shakibaei M. Development and phenotypic characterization of a high density in vitro model of auricular chondrocytes with applications in reconstructive plastic surgery. Histol Histopathol. 2006 May;21(5):467-76.

77.        Lorenz W, Sigrist G, Shakibaei M, Mobasheri A, Trautmann C. A hypothesis for the origin and pathogenesis of rheumatoid diseases. Rheumatol Int. 2006 May;26(7):641-54.

78.        Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A. Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann Anat. 2005 Nov;187(5-6):487-97.

79.        Mobasheri A, Richardson S, Mobasheri R, Shakibaei M, Hoyland JA. Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes. Histol Histopathol. 2005 Oct;20(4):1327-38.

80.        Goggs R, Vaughan-Thomas A, Clegg PD, Carter SD, Innes JF, Mobasheri A, et al. Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr. 2005;45(3):145-64.

81.        Mobasheri A, Dobson H, Mason SL, Cullingham F, Shakibaei M, Moley JF, et al. Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondrocytes in ovine articular cartilage. Cell Biol Int. 2005 Apr;29(4):249-60.

82.        Mobasheri A, Airley R, Hewitt SM, Marples D. Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays. Int J Oncol. 2005 May;26(5):1149-58.

83.        Mobasheri A, Gent TC, Womack MD, Carter SD, Clegg PD, Barrett-Jolley R. Quantitative analysis of voltage-gated potassium currents from primary equine (Equus caballus) and elephant (Loxodonta africana) articular chondrocytes. Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R172-80.

84.        Phillips T, Ferraz I, Bell S, Clegg PD, Carter SD, Mobasheri A. Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes. Vet J. 2005 Mar;169(2):216-22.

85.        Mobasheri A, Wray S, Marples D. Distribution of AQP2 and AQP3 water channels in human tissue microarrays. J Mol Histol. 2005 Feb;36(1-2):1-14.

86.        Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M. Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Ann N Y Acad Sci. 2004 Dec;1030:578-86.

87.        Arteaga MF, Gutierrez R, Avila J, Mobasheri A, Diaz-Flores L, Martin-Vasallo P. Regeneration influences expression of the Na+, K+-atpase subunit isoforms in the rat peripheral nervous system. Neuroscience. 2004;129(3):691-702.

88.        Duquette RA, Shmygol A, Vaillant C, Mobasheri A, Pope M, Burdyga T, et al. Vimentin-positive, c-kit-negative interstitial cells in human and rat uterus: a role in pacemaking? Biol Reprod. 2005 Feb;72(2):276-83.

89.        Schulze-Tanzil G, Mobasheri A, Clegg PD, Sendzik J, John T, Shakibaei M. Cultivation of human tenocytes in high-density culture. Histochem Cell Biol. 2004 Sep;122(3):219-28.

90.        Mobasheri A, Trujillo E, Bell S, Carter SD, Clegg PD, Martin-Vasallo P, et al. Aquaporin water channels AQP1 and AQP3, are expressed in equine articular chondrocytes. Vet J. 2004 Sep;168(2):143-50.

91.        Mobasheri A, Shakibaei M, Marples D. Immunohistochemical localization of aquaporin 10 in the apical membranes of the human ileum: a potential pathway for luminal water and small solute absorption. Histochem Cell Biol. 2004 Jun;121(6):463-71.

92.        Mobasheri A, Critchlow K, Clegg PD, Carter SD, Canessa CM. Chronic equine laminitis is characterised by loss of GLUT1, GLUT4 and ENaC positive laminar keratinocytes. Equine Vet J. 2004 Apr;36(3):248-54.

93.        Schulze-Tanzil G, Mobasheri A, de Souza P, John T, Shakibaei M. Loss of chondrogenic potential in dedifferentiated chondrocytes correlates with deficient Shc-Erk interaction and apoptosis. Osteoarthritis Cartilage. 2004 Jun;12(6):448-58.

94.        Trujillo E, Gonzalez T, Marin R, Martin-Vasallo P, Marples D, Mobasheri A. Human articular chondrocytes, synoviocytes and synovial microvessels express aquaporin water channels; upregulation of AQP1 in rheumatoid arthritis. Histol Histopathol. 2004 Apr;19(2):435-44.

95.        Mobasheri A, Airley R, Foster CS, Schulze-Tanzil G, Shakibaei M. Post-genomic applications of tissue microarrays: basic research, prognostic oncology, clinical genomics and drug discovery. Histol Histopathol. 2004 Jan;19(1):325-35.

96.        Schwab W, Schulze-Tanzil G, Mobasheri A, Dressler J, Kotzsch M, Shakibaei M. Interleukin-1beta-induced expression of the urokinase-type plasminogen activator receptor and its co-localization with MMPs in human articular chondrocytes. Histol Histopathol. 2004 Jan;19(1):105-12.

97.        Mobasheri A, Pestov NB, Papanicolaou S, Kajee R, Cozar-Castellano I, Avila J, et al. Expression and cellular localization of Na,K-ATPase isoforms in the rat ventral prostate. BJU Int. 2003 Nov;92(7):793-802.

98.        Mobasheri A, Marples D. Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology. Am J Physiol Cell Physiol. 2004 Mar;286(3):C529-37.

99.        Shakibaei M, Schulze-Tanzil G, Mobasheri A, Beichler T, Dressler J, Schwab W. Expression of the VEGF receptor-3 in osteoarthritic chondrocytes: stimulation by interleukin-1 beta and association with beta 1-integrins. Histochem Cell Biol. 2003 Sep;120(3):235-41.

100.      Goggs R, Carter SD, Schulze-Tanzil G, Shakibaei M, Mobasheri A. Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. Vet J. 2003 Sep;166(2):140-58.

101.      Mobasheri A, Fox R, Evans I, Cullingham F, Martin-Vasallo P, Foster CS. Epithelial Na, K-ATPase expression is down-regulated in canine prostate cancer; a possible consequence of metabolic transformation in the process of prostate malignancy. Cancer Cell Int. 2003 Jun 13;3(1):8.

102.      Clegg PD, Mobasheri A. Chondrocyte apoptosis, inflammatory mediators and equine osteoarthritis. Vet J. 2003 Jul;166(1):3-4.

103.      Mobasheri A, Evans I, Martin-Vasallo P, Foster CS. Expression and cellular localization of Na,K-ATPase isoforms in dog prostate in health and disease. Ann N Y Acad Sci. 2003 Apr;986:708-10.

104.      Floyd R, Mobasheri A, Martin-Vasallo P, Wray S. Na,K-ATPase isoforms in pregnant and nonpregnant rat uterus. Ann N Y Acad Sci. 2003 Apr;986:614-6.

105.      Shakibaei M, Mobasheri A. Beta1-integrins co-localize with Na, K-ATPase, epithelial sodium channels (ENaC) and voltage activated calcium channels (VACC) in mechanoreceptor complexes of mouse limb-bud chondrocytes. Histol Histopathol. 2003 Apr;18(2):343-51.

106.      Richardson S, Neama G, Phillips T, Bell S, Carter SD, Moley KH, et al. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage. 2003 Feb;11(2):92-101.

107.      Mobasheri A, Vannucci SJ, Bondy CA, Carter SD, Innes JF, Arteaga MF, et al. Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis. Histol Histopathol. 2002 Oct;17(4):1239-67.

108.      Mobasheri A. Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis. Med Hypotheses. 2002 Mar;58(3):193-7.

109.      Mobasheri A, Neama G, Bell S, Richardson S, Carter SD. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Cell Biol Int. 2002;26(3):297-300.

110.      Francis MJ, Lees RL, Trujillo E, Martin-Vasallo P, Heersche JN, Mobasheri A. ATPase pumps in osteoclasts and osteoblasts. Int J Biochem Cell Biol. 2002 May;34(5):459-76.

111.      Mobasheri A, Carter SD, Martin-Vasallo P, Shakibaei M. Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes. Cell Biol Int. 2002;26(1):1-18.

112.      Mobasheri A, Oukrif D, Dawodu SP, Sinha M, Greenwell P, Stewart D, et al. Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization. Histol Histopathol. 2001 Jan;16(1):141-54.

113.      Mobasheri A, Avila J, Cozar-Castellano I, Brownleader MD, Trevan M, Francis MJ, et al. Na+, K+-ATPase isozyme diversity; comparative biochemistry and physiological implications of novel functional interactions. Biosci Rep. 2000 Apr;20(2):51-91.

114.      Brownleader MD, Hopkins J, Mobasheri A, Dey PM, Jackson P, Trevan M. Role of extensin peroxidase in tomato (Lycopersicon esculentum Mill.) seedling growth. Planta. 2000 Mar;210(4):668-76.

115.      Mobasheri A. Regulation of Na+, K+-ATPase density by the extracellular ionic and osmotic environment in bovine articular chondrocytes. Physiol Res. 1999;48(6):509-12.

116.      Mobasheri A, Martin-Vasallo P. Epithelial sodium channels in skeletal cells; a role in mechanotransduction? Cell Biol Int. 1999;23(4):237-40.

117.      Trujillo E, Alvarez de la Rosa D, Mobasheri A, Gonzalez T, Canessa CM, Martin-Vasallo P. Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes. Histol Histopathol. 1999 Oct;14(4):1023-31.

118.      Trujillo E, Alvarez de la Rosa D, Mobasheri A, Avila J, Gonzalez T, Martin-Vasallo P. Sodium transport systems in human chondrocytes. I. Morphological and functional expression of the Na+,K(+)-ATPase alpha and beta subunit isoforms in healthy and arthritic chondrocytes. Histol Histopathol. 1999 Oct;14(4):1011-22.

119.      Mobasheri A, Golding S, Pagakis SN, Corkey K, Pocock AE, Fermor B, et al. Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts. Cell Biol Int. 1998;22(7-8):551-62.

120.      Mobasheri A. Brefeldin A influences the cell surface abundance and intracellular pools of low and high ouabain affinity Na+, K(+)-ATPase alpha subunit isoforms in articular chondrocytes. Histol Histopathol. 1999 Apr;14(2):427-38.

121.      Brownleader MD, Jackson P, Mobasheri A, Pantelides AT, Sumar S, Trevan M, et al. Molecular aspects of cell wall modifications during fruit ripening. Crit Rev Food Sci Nutr. 1999 Mar;39(2):149-64.

122.      Mobasheri A. Correlation between [Na+], [glycosaminoglycan] and Na+/K+ pump density in the extracellular matrix of bovine articular cartilage. Physiol Res. 1998;47(1):47-52.

123.      Mobasheri A, Mobasheri R, Francis MJ, Trujillo E, Alvarez de la Rosa D, Martin-Vasallo P. Ion transport in chondrocytes: membrane transporters involved in intracellular ion homeostasis and the regulation of cell volume, free [Ca2+] and pH. Histol Histopathol. 1998 Jul;13(3):893-910.

124.      Basavappa S, Mobasheri A, Errington R, Huang CC, Al-Adawi S, Ellory JC. Inhibition of Na+, K+-ATPase activates swelling-induced taurine efflux in a human neuroblastoma cell line. J Cell Physiol. 1998 Feb;174(2):145-53.

125.      Mobasheri A, Hall AC, Urban JP, France SJ, Smith AL. Immunologic and autoradiographic localisation of the Na+, K(+)-ATPase in articular cartilage: upregulation in response to changes in extracellular Na+ concentration. Int J Biochem Cell Biol. 1997 Apr;29(4):649-57.

126.      Mobasheri A, Errington RJ, Golding S, Hall AC, Urban JP. Characterization of the Na+, K(+)-ATPase in isolated bovine articular chondrocytes; molecular evidence for multiple alpha and beta isoforms. Cell Biol Int. 1997 Apr;21(4):201-12.

Papers in Press
  1. Shakibaei M, Shayan P, Busch F, Aldinger C, Buhrmann C, Lueders C, Mobasheri A. Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: Potential Role of Runx2 Deacetylation. PLoS ONE (in press).
  2. Mobasheri A, Henrotin Y, Biesalski H-K, Shakibaei M. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. International Journal of Molecular Sciences 2012, 13, 4202-4232.
  3. Hdud IM, El-Shafei AA, Loughna P, Barrett-Jolley R, Mobasheri A. Expression of Transient Receptor Potential Vanilloid (TRPV) Channels in Different Passages of Articular Chondrocytes. International Journal of Molecular Sciences 2012, 13, 4433-4445.
Book Chapters:

Goggs R, Vaughan-Thomas A, Innes JF, Clegg PD, Carter SD, Shakibaei M, Schwab W, Bondy CA, Mobasheri A. Nutritional, nutraceutical and micronutrient remedies for osteoarthritis. In: Focus on Arthritis Research. ISBN 1-59033-988-6. Editor: Frank Columbus, pp. 151-174. 2004. Nova Science Publishers, Inc., New York.

https://www.novapublishers.com/catalog/product_info.php?products_id=1624

 

Mobasheri A, Barrett-Jolley R, Carter SD, Martín-Vasallo P, Schulze-Tanzil G, Shakibaei M. Functional Roles of Mechanosensitive Ion Channels, ß1 Integrins and Kinase Cascades in Chondrocyte Mechanotransduction. In: Mechanosensitivity in Cells and Tissues. ISBN 5-7695-2590-8 Moscow: Academia; 2005. Editors: Andre Kamkin, Irina Kiseleva, pp. 434-451.

http://www.ncbi.nlm.nih.gov/pubmed/21290779

 

Mobasheri A, Barrett-Jolley R, Shakibaei M, Canessa CM, Martín-Vasallo P. Enigmatic Roles of the Epithelial Sodium Channel (ENaC) in Articular Chondrocytes and Osteoblasts: Mechanotransduction, Sodium Transport or Extracellular Sodium Sensing? In: Mechanosensitivity in Cells and Tissues. ISBN 5-7695-2590-8 Moscow: Academia; 2005. Editors: Andre Kamkin, Irina Kiseleva, pp. 452-464.

http://www.ncbi.nlm.nih.gov/pubmed/21290775

 

Mobasheri A, Vannucci SJ, Carter SD, Innes JF, Shakibaei M, Martín-Vasallo P, Bondy CA. Endocrine, cytokine and hypoxia mediated regulation of glucose transport in chondrocytes: a key to understanding cartilage development and degradation in osteoarthritis. In: Arthritis Research. ISBN 1-59454-465-4. Editor: Frank Columbus, pp. 1-41. 2005. Nova Science Publishers, Inc., New York.

https://www.novapublishers.com/catalog/product_info.php?products_id=3628

 

Airley RE, Mobasheri A. Novel pathways and targets for the development of anti-cancer therapeutics 1: glucose transport and metabolism in cancer. In: Lung Cancer in Women. ISBN 978-1-60021-659-6. Editor: Varetta N. Torres, pp. 45-71. 2007. Nova Science Publishers, Inc., New York.

https://www.novapublishers.com/catalog/product_info.php?products_id=5633

 

Mobasheri A, Bondy CA, Moley K, Mendes AF, Rosa SC, Richardson SM, Hoyland JA, Barrett-Jolley R, Shakibaei M. Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines. In: Advances in Anatomy Embryology and Cell Biology. Volume 200, pp. 1-84. ISBN 978-3-540-78898-0. Editors: Beck F, Clasca F, Frotscher M, Haines DE, Hirokawa N, Kmiec Z, Korf H-W, Marani E, Putz R, Sano Y, Schiebler TH, Timmermans J-P. 2008. Springer-Verlag Berlin, Heidelberg.

 

Shakibaei M, Csaki C, Mobasheri A. Diverse roles of integrin receptors in articular cartilage. In: Advances in Anatomy Embryology and Cell Biology. Volume 197, pp. 1-60. Editors: Beck F, Clasca F, Frotscher M, Haines DE, Hirokawa N, Kmiec Z, Korf H-W, Marani E, Putz R, Sano Y, Schiebler TH, Timmermans J-P. 2008. Springer-Verlag Berlin, Heidelberg.

Mobasheri A, Dart C, Barrett-Jolley R. Potassium ion channels in articular chondrocytes. Putative roles in mechanotransduction, metabolic regulation and cell proliferation. In: Mechanosensitive Ion Channels. ISBN 978-1-4020-6425-8. Editors: Andre Kamkin, Irina Kiseleva, pp. 157-178. 2008. Springer-Verlag, Berlin - Heidelberg.

http://www.springer.com/life+sciences/cell+biology/book/978-1-4020-6425-8

Mobasheri A, Cathro HP, German AJ, Marples D, Martín-Vasallo P, Canessa C. Applications of tissue microarrays in renal physiology and pathology. In: Renal and Urinary Proteomics: Methods and Protocols. ISBN 978-3-527-31974-9. Editor: Thongboonkerd, V., pp. 97-118. 2010. Wiley-Blackwell/Wiley VCH Verlag GmbH &Co. KGaA, Weinheim.

http://www.wiley-vch.de/publish/en/AreaOfInterestBE00/availableTitles/3-527-31974-3/?sID=cst7rh7kcoume3kt0usufob975

Mobasheri A, Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M. Nutritional biochemistry of curcumin (diferuloylmethane) and a review of its biological actions on articular chondrocytes. In: Handbook of Nutritional Biochemistry: Genomics, Metabolomics and Food Supply. ISBN 978-1-60741-916-7. Editors: Sondre Haugen, Simen Meijer, 289-315. 2010. Nova Science Publishers, Inc., New York.

https://www.novapublishers.com/catalog/product_info.php?products_id=10999

 

Mobasheri A, Richardson SM, Hoyland JA, Buhrmann C, Shakibaei M. From Multipotent Cells to Fully Differentiated Connective Tissue Cells for Regenerative Medicine: Emerging Applications of Mesenchymal Stem Cells. In: Regenerative Medicine and Tissue Engineering: Cells and Biomaterials. ISBN 978-953-307-663-8. Editor: Daniel Eberli, pp. 83-106. 2011. InTech, Rijeka, Croatia.

http://www.intechopen.com/articles/show/title/from-multipotent-cells-to-fully-differentiated-connective-tissue-cells-for-regenerative-medicine-eme

Mobasheri A, Aldinger C, Shakibaei M. Inflammation in rheumatic and arthritic diseases. Role of dietary phytochemicals. In: Inflammation Lifestyle and Chronic Disease: The Silent Link. ISBN 978-1-4398-3989-8. Editors: Bharat B. Aggarwal, Sunil Krishnan, Sushovan Guha, pp. 101-130. 2012. CRC Press, Taylor and Francis Group, Boca Raton – London - New York

http://www.taylorandfrancis.com/books/details/9781439839898/

Book Chapters in Press:

Mobasheri A, Asplin K, Clutterbuck A, Shakibaei M. Nutraceuticals: from Research to Legal and Regulatory Affairs. Nonpharmacological Therapies in the Management of Osteoarthritis. Editors: Yves Henrotin, Kim Bennell and Francois Rannou. 2011, Bentham Science Publishers, UAE.

http://www.benthamscience.com/ebooks/

Mobasheri, A. Mammary glands, aquaporins and milk production. In: Milk Production. ISBN 978-1-62100-061-7. Editor: Frank Columbus. 2012 Nova Science Publishers, Inc., New York.

https://www.novapublishers.com/catalog/product_info.php?products_id=28357

Mobasheri A, Shakibaei M. The Role of Proinflammatory Cytokines in Osteoarthritis: New Therapeutic Approaches Using Anti-cytokine Therapy and NF-κB Inhibitors. In: Cytokines: Mechanisms, Functions and Abnormalities. ISBN 978-1-62100-929-0. Editor: Masoud H. Manjili. 2012. Nova Science Publishers, Inc., New York.

https://www.novapublishers.com/catalog/product_info.php?products_id=29831

Mobasheri A, Biesalski H-K, Shakibaei M, Henrotin Y. Antioxidants and Osteoarthritis. In: Handbook of System Biology of Free Radicals and Anti-Oxidants. Editor: Prof. I. Laher, University of British Columbia, Vancouver, Canada. 2012. Springer-Verlag, Berlin - Heidelberg.

 

Mobasheri A, Kelly S, Clutterbuck AL, Buhrmann C, Shakibaei M. Three-Dimensional, High-Density and Tissue Engineered Culture Models of Articular Cartilage. In: Replacing animal models: a practical guide to creating and using biomimetic alternatives. Editor: Jamie Davies, University of Edinburgh. 2012. Wiley-Blackwell.

http://edinburgh.academia.edu/JamieDavies/Books/964322/Replacing_Animal_Models_a_practical_guide_to_creating_and_using_culture-based_biomimetic_alternatives

Mobasheri A. Tissue MicroArray (TMA) Technology and its Potential Applications in Toxicology and Toxicological Immunohistochemistry. In: Toxicological Immunohistochemistry. Editors: S.A. Aziz and R. Mehta, University of Ottawa, Ottawa, Canada. 2012. Springer-Verlag.

Mobasheri A, Moskaluk CA, Marples D, Shakibaei M. The Role of Aquaporins in Human Synovitis. In: Arthritis: Types, Treatment and Prevention. ISBN 978-1-61470-719-6. Editor: Marc N. Pelt. 2012. Nova Science Publishers, Inc., New York.

https://www.novapublishers.com/catalog/product_info.php?products_id=27728