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Scientific Program

THURSDAY, MARCH 30, 2017
14:00-15:00 ORAL PRESENTATIONS I
Hall A
Chairperson Itai Berger, Israel
14:00 MODELLING THE OPTIMAL TARGET AGE GROUP FOR SEASONAL INFLUENZA VACCINATION IN JAPAN
Shinya Tsuzuki, UK
14:09 HEPATIC AND/OR SPLENIC ABSCESS IS A GOOD CLINICAL PREDICTOR FOR PEDIATRIC MELIOIDOSIS
Supatjaree Chanvitan, Thailand
14:18 THE STRONGKIDS NUTRITIONAL SCREENING TOOL IN HOSPITALIZED CHILDREN OF A PORTUGUESE GENERAL HOSPITAL
Juliana Costa Maciel, Portugal
14:27 THE INVESTIGATION OF OCCUPATIONAL EXPERIENCE OF OBSTETRICIANS IN TERMS OF DRUGS USE IN PREGNANCY AND TERATOGENICITY
Ahmet Akici, Turkey
14:36 NEUTROPHIL LYMPHOCYTE AND NEUTROPHIL PLATELET RATIOS IN CHILDREN WITH AUTISM SPECTRUM DISORDERS; A PRELIMINARY STUDY
Nagihan Cevher Binici, Turkey
14:45 DOES CLINICAL GOVERNANCE APPLY TO THE ADVANCE CARE PLANS?
Shashwat Saran. UK
14:54-15:00 Discussion
14:00-15:00 ORAL PRESENTATIONS II
Hall B
Chairperson Ami Ballin, Israel
14:00 ANOMALOUS GAIT: A VERY RARE MYOPATHY
Vera Gonçalves, Portugal
14:09 PIGMENTED HYPERTRICHOTIC DERMATOSIS AND INSULIN DEPENDENT DIABETES:
MANIFESTATIONS OF A RARE SYNDROME
Siham Mansouri, Morocco
14:18 PARRY-ROMBERG SYNDROME:  A CASE REPORT
Siham Mansouri, Morocco
14:27 INTER-RATER RELIABILITY OF USING COMFORT-B SCALE IN PEDIATRIC INTENSIVE CARE UNIT
Rujira Buntharikpornpun, Thailand
14:36 SUCCESSFUL USE OF RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR (R-TPA) FOR MANAGEMENT OF CHYLOTHORAX ASSOCIATED WITH CENTRAL VENOUS THROMBOSIS AFTER NEONATAL CARDIAC SURGERY
Sameh Rabie Ismail, Saudi Arabia
14:45-15:00 Discussion
15:00-16:30 THE FIRST UNPROVOKED VENOUS THROMBO-EMBOLIC EVENT
Hall A
Capsule Venous thromboembolic disease is increasingly recognized in neonates and children. Treatment is generally extrapolated from adult guidelines. In most pediatric patients, treatment consists of heparin (unfractionated heparin or low-molecular- weight heparin [LMWH]) followed by LMWH or vitamin K antagonists. The safety and efficacy of direct oral anticoagulants (DOACs) are currently studied in children in large international, multicenter trials. The duration of antithrombotic therapy is extrapolated from adult guidelines, as well. However, do we need to treat children with a first unprovoked thrombosis indefinitely as is recommended in adults?
Chairperson Heleen Van Ommen, The Netherlands
 15:00 Antithrombotic treatment in children: Past, present, future
Heleen Van Ommen, The Netherlands
 15:30-16:30 Debate: All children with a first unprovoked venous thromboembolic event should be treated with anticoagulation indefinitely
 15:30 Yes: Mattia Rizzi, Switzerland
 15:50 No: Claudio Molinari, Italy
 16:10 Discussion
15:00-16:30 METHYLPHENIDATE BENEFITS FOR CHILDREN AND ADOLESCENTS WITH ADHD
Hall B
Capsule • Methylphenidate is commonly prescribed for ADHD.
• Methylphenidate has been used for this indication for more than 50 years.
• What is the quality of clinical research evidence on benefits for ADHD patients?
• Did something go wrong in the past?
• How can we amend and expand our evidence based on benefits of methylphenidate for ADHD? 
Chairperson Christian Gluud, Denmark
 15:00 Benefits of methylphenidate for children and adolescents with ADHD?  Cochrane systematic review
Ole Jakob Storebø, Denmark
 15:30-16:30 Debate: What are the benefits of methylphenidate for children and adolescents with attention deficit hyperactivity disorder?
 15:30 Pro: Marcel Romanos, Germany
 15:50 Con: Ole Jakob Storebø, Denmark
 16:00 Con: Christian Gluud, Denmark
 16:10 Discussion
16:50-18:20 HPV VACCINE EFFECTIVENESS AND SAFETY
Hall A
Capsule HPV vaccines have been introduced in over 60 countries with dramatic reductions in viral prevalence, genital warts and advanced pre-neoplastic lesions. In parallel these vaccines are implicated in non-scientific debates as responsible for a number of adverse events. These claims have resulted in serious damage to the vaccination programs in Japan, Colombia and Denmark.
Chairperson F. Xavier Bosch, Spain
 16:50 HPV vaccines:  Results after 10 years of vaccination
F. Xavier Bosch, Spain
 17:20 HPV vaccines safety assessment: Current views in Europe
Pier Luigi Lopalco, Italy
 17:50 HPV vaccine scares: Impact in Europe and efforts to be made
Christian Munk, Denmark
16:50-18:20 METHYLPHENIDATE HARMS FOR CHILDREN AND ADOLESCENTS WITH ADHD
Hall B
Capsule • Methylphenidate is commonly prescribed for ADHD.
• Methylphenidate has been used for this indication for more than 50 years.
• What is the quality of clinical research evidence on benefits for ADHD patients?
• Did something go wrong in the past?
• How can we amend and expand our evidence based on harms of methylphenidate for ADHD? 
Chairperson Christian Gluud, Denmark
 16:50 Harms of methylphenidate for children and adolescents with ADHD?  Cochrane systematic review
Ole Jakob Storebø, Denmark
 17:20-18:20 Debate: What are the harms of methylphenidate for children and adolescents with attention deficit hyperactivity disorder?
17:20 Pro: Jan Buitelaar, The Netherlands
17:40 Con: Ole Jakob Storebø, Denmark
17:50 Con: Christian Gluud, Denmark
18:00 Discussion
18:30-19:30 OPENING SESSION
Hall A
18:30 Greetings
Ami Ballin, Israel
18:45 Fatty liver in children: The emerging 21st century epidemic. How to cope? How to treat?
Shimon Reif, Israel
19:30 NETWORKING RECEPTION
FRIDAY, MARCH 31, 2017
08:30-10:00 CONTROVERSIES IN NEONATAL CARE
Hall A
Capsule

The currently existing prescription opioid epidemic has resulted in a dramatic increase in newborn infants born with Neonatal Abstinence Syndrome (NAS). Old and new ways of treating these addicted neonates will be discussed during this session.

Total body cooling has become standard of care for the treatment of neonates with perinatal asphyxia. Many of these newborn infants are treated with a myriad of medications. This session will provide a pro/con discussion on the need for more intensified therapeutic drug monitoring in these infants during and after induced hypothermia.
Chairpersons John van den Anker, USA/Switzerland
Karel Allegaert, Belgium 
 08:30 Neonatal abstinence syndrome
Karel Allegaert, Belgium
 09:00-10:00 Debate: Neonates treated with hypothermia need more intensive therapeutic drug monitoring (TDM)
 09:00 Pro: John van den Anker, USA/Switzerland
 09:20 Con:  Karel Allegaert, Belgium
 09:40 Discussion
08:30-10:00 FEEDING THE NEURO-DISABLED CHILD
Hall B
Capsule Many neuro-disabled children suffer from failure to thrive which might have influence on their cognitive functioning. However, depending on the severity of the cerebral palsy these children will follow their own growth chart. Feeding difficulties and intolerance are major issues in these children and there is a lot of debate about the appropriate treatment. 
Chairpersons Peter Sullivan, UK
Shimon Reif, Israel
08:30-09:00 Overview of feeding difficulties in relation with growth in neuro-disabled children
Peter Sullivan, UK
09:00-10:00 Debate: Too many children with cerebral palsy are fed by gastrostomy and too soon
09:00 Pro: Jessie Hulst, The Netherlands  
09:20 Con: Peter Sullivan, UK
09:40 Discussion
10:30-12:00 BREASTFEEDING AND CHILDHOOD IQ
Hall A
Capsule A large number of studies suggest that the IQ of breastfed infants is higher than that of formula fed infants. However, there is a hot debate whether this is due to the milk/breastfeeding, or due to the characteristics and environment of women who choose to breastfeed vs those who choose formula feeding. This debate is not merely theoretical, but rather has clinical implications and ramifications for women who choose not to breastfeed.
Chairperson Gideon Koren, Canada
10:30-12:00 Debate: Does breastfeeding affect IQ?
10:30 Con: Rafael Gorodischer, Israel 
11:05 Pro: Gideon Koren, Canada
11:40 Discussion
10:30-12:00 ORAL PRESENTATIONS III
Hall B
Chairperson Ami Ballin, Israel
10:30 HOW MUCH DO PARENTS KNOW ABOUT ADHD?
Alexandra Fernandes, Portugal
10:40 PREVALENCE OF INFECTION IN CHILDREN WITH CHOLESTASIS ADMITTED TO CIPTO MANGUNKUSUMO HOSPITAL 2010-2015
Silvi Risdia Lina, Indonesia
10:50 SPACE-TIME CLUSTERING OF NECROTIZING ENTEROCOLITIS SUPPORTS THE EXISTENCE OF TRANSMISSIBLE CAUSES
Margareta Ahle, Sweden
11:00 NEONATAL PHOTOTHERAPY – TURQUOISE IS THE NEW BLUE
Graham Hart, UK
11:10 EFFECT OF GUIDELINES BASED MANAGEMENT ON THE EARLY POST-OPERATIVE OUTCOME AFTER BLALOCK-TAUSING SHUNT
Sameh Rabie Ismail, Saudi Arabia
11:20 RADIOFREQUENCY CATHETER ABLATION OF TACHYARRHYTHMIA IN SMALL CHILDREN
Liliya Svintsova, Russia
11:30 SYSTEMATIC REVIEW OF METHYLPHENIDATE HARMS FOR CHILDREN AND ADOLESCENTS WITH ADHD
Ole Jakob Storebø, Denmark
11:40 CHANGING ATTITUDES IN PAEDIATRIC VASCULAR ACCESS FOR HAEMODIALYSIS
Petrut Gogalniceanu, UK
11:50-12:00 Discussion
13:00-14:30 JOINT PAIN IN CHILDREN AND ADOLESCENTS
Hall A
Capsule Joint hypermobility is a very common occurrence in the pediatric age. Occasionally it can lead to signs and symptoms, in particular to arthralgia with or without arthritis. Diagnosis is very simple and based on clinical findings alone. A correct diagnosis can avoid multiple unnecessary testing. Treatment is based on reassurance, advice, and joint protection. In severe cases physical therapy plays a major role.    
Chairperson Rolando Cimaz, Italy        
13:00-13:30 Benign joint hypermobility syndrome (BJHS)
Rolando Cimaz, Italy
13:30-14:30 Debate: Joint pain in children and adolescents: Clinical or laboratory investigations?
13:30 Pro: Francesco Zulian, Italy
13:50 Con: Hans-Iko Huppertz, Germany
14:10 Discussion
13:00-14:30 FEEDING THE SICK CHILD
Hall B
Capsule It has been advocated for years that it is beneficial to start with early parenteral or enteral nutrition in sick children. However, early nutrition might interfere with the autophagy process and influence recovery.  
Chairpersons Koen Joosten, The Netherlands
Shimon Reif, Israel        
13:00-13:30 Overview of the acute stress response in sick children
Koen Joosten, The Netherlands
13:30-14:30 Debate: Hypocaloric feeding in sick children is harmful
13:30 Pro: Sascha Verbruggen, The Netherlands
13:50 Con: Rosan Meyer, UK
14:10 Discussion
14:30-16:00 ROLE OF CORTICOSTEROIDS AS ADJUNCTIVE TREATMENT IN DEFINED BACTERIAL INFECTIONS: PROS AND CONS
Hall A
Capsule Corticosteroids are often considered as the magic bullet in the management of inflammatory processes. Because bacterial infections are usually associated with local inflammation, which might augment the damage caused by the infection, adjunctive steroid administration can be helpful. However, the role of corticosteroids in the treatment of bacterial infections is controversial.
Chairpersons Pablo Rojo, Spain
Gilat Livni, Israel
14:30 Steroids in bacterial meningitis? Empiric antibiotics?
Sharon Nachman, USA
14:55 Steroids in septic arthritis? Empiric antibiotics?
Gilat Livni, Israel
15:20 Steroids in pneumonia with pleural effusion? Empiric antibiotics?
Pablo Rojo, Spain
15:45 Discussion
14:30-16:00 KAWASAKI DISEASE
Hall B
Capsule Kawasaki disease is a febrile illness which pediatricians should know. It is in the differential diagnosis of any febrile young child, and must be recognized promptly since early diagnosis can lead to correct treatment and avoid life-threatening complications such as coronary artery aneurysms. Different treatment options are now available, in particular for refractory cases.
Chairperson Rolando Cimaz, Italy
14:30-15:00 Update of Kawasaki disease
Mike Levin, UK
15:00-16:00 Debate: Is Kawasaki disease a common or rare disease?
15:00 Pro: Jordi Anton, Spain
15:20 Con: Tamás Constantin, Hungary
15:40 Discussion
16:30-18:00 CONTROVERSIES IN THE MANAGEMENT OF ACUTE GASTROENTERITIS IN CHILDREN
Hall A
Capsule Literature review reveals considerable contrasting data regarding the management of acute gastroenteritis in children. Controlled studies have shown that antibiotic therapy is efficacious only for few causes of bacterial gastroenteritis (mainly shigellosis), ineffective in others and maybe even harm in Shiga-toxin producing E. coli (STEC) gastroenteritis by increasing toxin production and the risk of hemolytic-uremic syndrome. Likewise, when to use probiotics, anti-emetics or anti-diarrheal agents is also unclear.
Chairpersons Marc Benninga, The Netherlands
J. Hans Hoekstra, The Netherlands
Shai Ashkenazi, Israel
16:30 Antimicrobial therapy in acute gastroenteritis
Shai Ashkenazi, Israel
16:55 Probiotics in acute gastroenteritis
Sharon Nachman, USA
17:20 Pharmacological medications in acute gastroenteritis
J. Hans Hoekstra, The Netherlands
17:45 Discussion
16:30-18:00 AUTISM IN GIRLS
Hall B
Capsule There is a “gender gap” in autism diagnosis, commonly referenced consensus ratio of ~4:1.  The male bias in autism has attracted a variety of research but currently we know shockingly little about whether and how autism might be different in girls and boys, or why. Is it possible that current screening/diagnostic instruments may not be reliable for identifying ASD in girls? In this session we will discuss the nosological and diagnostic challenge, as well as the biological theories for gender difference in autism – anatomic, genetic, hormonal theories and pathways.
Chairperson Itai Berger, Israel
16:30 Autism in girls: Unmet needs and translational research   
Itai Berger, Israel 
16:50-17:30 Autism in girls: Misunderstood, misdiagnosed or missed altogether?
16:50 Understanding autism in the light of gender
Meng-Chuan Lai, Canada
17:15 The nosological and diagnostic challenge
Michael Absoud, UK
17:40 Discussion
SATURDAY, APRIL 1, 2017
08:30-10:00 DEBATE: HOW TO IMPROVE THE ACCEPTANCE OF INFLUENZA VACCINES
Hall A
Capsule Although vaccines against influenza are available, this infection is still associated with significant morbidity and mortality. For example, in the US seasonal influenza causes an annual average of ~220,000 hospitalizations and ~24,000 deaths (JAMA 8/2010; 59:1057-62), with the conclusion of the CDC that influenza is the leading cause of vaccine-preventable deaths in the US. This relates to frequent antigenic changes of the virus, resulting from recombination events and point mutations that occur during replication, and low coverage of influenza vaccines. How to increase the coverage of influenza vaccines is controversial.
Chairpersons Ulrich Heininger, Switzerland
Pablo Rojo, Spain
Shai Ashkenazi, Israel
08:30 Introduction: Vaccination against influenza: A special challenge
Shai Ashkenazi, Israel
08:50 Targeted vaccination of high-risk groups is the key
Pablo Rojo, Spain
09:15 Universal vaccination is the key
Ulrich Heininger, Switzerland
09:40 Discussion
08:30-10:00 IF CONVENTIONAL TREATMENT FAILS IN FUNCTIONAL CONSTIPATION: RECTAL THERAPY
YES OR NO?
Hall B
Capsule Constipation is probably the most common gastrointestinal problem in childhood. In many children conventional treatment with dietary advice, toilet training and oral laxatives is sufficient to treat these children. However, in some children more intensive treatment is necessary. Is rectal therapy in those cases a good solution?
Chairperson Marc Benninga, The Netherlands
08:30-09:00 Childhood constipation (definition, etiology, diagnostics, treatment)
Marc Benninga, The Netherlands
09:00-10:00 Debate: Anorectal irrigation/surgery is sometimes necessary or unnecessary in childhood constipation
09:00 Necessary: Justin de Jong, The Netherlands
09:20 Unnecessary: Alexander von Gontard, Germany
09:40 Discussion
10:30-12:00 NON-MENDELIAN INHERITANCE: IMPRINTING DISORDERS, CONGENITAL DISEASES WITH COMMON UNDERLYING (EPI)GENETIC AETIOLOGIES
Hall A
Capsule Imprinting disorders (IDs) are a group of rare but probably underdiagnosed congenital diseases affecting growth, development and metabolism. They are caused by changes in gene regulation (‘epigenetic mutation’), gene dosage and – rarely – in gene or genomic sequences.  The term genomic imprinting describes the expression of specific genes in a parent-of-origin-specific manner – that is, they are expressed only from the maternal or from the paternal gene copy, but not biparentally.  We will discuss theses IDs describing the clinical features, and the specific imprinting defects.
Chairpersons Dorit Lev, Israel
Arnold Munnich, France
10:30-11:10 Epigenetics, genomic imprinting: What does it mean?
Dorit Lev, Israel
11:10-11:50 The clinical and molecular findings in pediatric imprinting disorders (Angelman syndrome,  Prader-Willi syndrome, growth syndromes)
Arnold Munnich, France
11:50-12:00 Discussion
10:30-12:00 HELICOBACTER PYLORI: TO TEST OR NOT TO TEST? TO TREAT OR NOT TO TREAT?
Hall B
Capsule There is a debate if helicobacter pylori should be tested in children with abdominal pain. In case this bacteria is found in these children, should we consequently treat these children?
Chairperson Marc Benninga, The Netherlands
10:30-11:00 Childhood helicobacter pylori (definition, etiology, diagnostics, treatment)
Sibylle Koletzko, Germany
11:00-12:00 Debate: Diagnostics and treatment of Hp in children with abdominal pain: Necessary or unnecessary?
11:00 Necessary: Patrick Bontems, Belgium
11:20 Unnecessary: Petronella Mourad-Baars, The Netherlands
11:40 Discussion
13:00-14:30 ATOPIC ECZEMA
Hall A
Capsule Are children and adolescents with food allergy more prone to have eczema?
Should we send children with eczema to test the possibility that they might suffer from food allergy?
Chairperson Georges Casimir, Belgium
13:00 Is food allergy the cause of atopic eczema?
Anthony Dubois, The Netherlands
13:35 Treatment of severe atopic eczema
Sami Bahna, USA
14:10 Discussion
13:00-14:30 FUNCTIONAL ABDOMINAL PAIN: PHARMACOLOGICAL TREATMENT OR NON-PHARMACOLOGICAL TREATMENT?
Hall B
Capsule Functional abdominal pain, including irritable bowel syndrome are common clinical entities in children. There is, however little evidence available how to treat these children, either pharmacological or non-pharmacological.
Chairperson Marc Benninga, The Netherlands
13:00-13:30 Functional abdominal pain in childhood
Robert Mark Beattie, UK
13:30-14:30 Debate: Pharmacological treatment of functional abdominal pain in childhood
13:30 Pro: Merit Tabbers, The Netherlands
13:50 Con: Arine Vlieger, The Netherlands
14:10 Discussion
14:30-16:00 INFLAMMATORY RESPIRATORY DISEASE
Hall A
Capsule Are there any gender differences in the prognosis of acute or chronic diseases in children and adolescents? Are there any differences associated with chromosomes? hormones? Cytokines?
Do animal models help us in answering these questions?
Chairperson Anthony Dubois, The Netherlands
14:30 Sex and inflammatory respiratory diseases in children
Georges Casimir, Belgium
15:05 The dilemma of cough in children
Sami Bahna, USA
15:40 Discussion
14:30-16:00 HYPERTENSION IN CHILDHOOD OBESITY
Hall B
Capsule Obesity associated hypertension is an emerging problem in childhood. Hypertension adds to other cardiovascular risk factors that come with obesity. Obesity induced hypertension is sometimes hard to diagnose as the rise in blood pressure in obese children may be most pronounced during the night. There is controversy about the threshold of blood pressure for starting medication as well as about the general approach of these patients. Some feel that medication should not be prescribed at all as long as weight reduction is not achieved, others promote a combined approach given the extreme cardiovascular burden in these children.
Chairpersons Jaap Groothoff, The Netherlands
Joana Kist-van Holthe, The Netherlands
14:30-15:00 Overview of mechanisms and outcomes of hypertension in children with obesity
Elke Wuehl, Germany
15:00-16:00 Debate: Anti-hypertensive medication is always indicated in obesity-associated hypertension
15:00 Pro: Elke Wuehl, Germany
15:20 Con: Kjell Tullus, UK
15:40 Discussion
16:30-18:00 NOVEL PEDIATRIC ISSUES
Hall A
Chairperson Sami Bahna, USA
16:30 The recent controversy in feeding infants to prevent allergy
Anthony Dubois, The Netherlands
17:05 Immunologic inflammation and cardio-metabolic disorders in cystic fibrosis
Georges Casimir, Belgium
17:40 Discussion
16:30-18:00 ANTIBIOTIC PROPHYLAXIS IN VESICO-URETERAL REFLUX AND OBSTRUCTIVE UROPATHY
Hall B
Capsule There is ongoing controversy about the efficacy of antibiotic prophylaxis in children with vesico-ureteral reflux.  Some advocate that prophylaxis may both reduce the rate of urinary tract infections (UTI) and hence the occurrence of renal damage, others claim that antibiotic prophylaxis only reduces the rate of non-febrile UTI and may even lead to a higher number of febrile UTI’s and concurrent renal damage.
Chairperson Tom P.V.M. de Jong, The Netherlands
16:30-17:00 Overview of renal damage caused by obstructive uropathy and vesico-urteral reflux
Per Brandstrom, Sweden
17:00-18:00 Debate: Antibiotic prophylaxis is indicated in all patients with high grade or obstructive uropathy
17:00 Pro: Per Brandstrom, Sweden
17:20 Con: Kjell Tullus, UK
17:40 Discussion